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Journal of the American Podiatric Medical Association, Vol 80, Issue 8 414-418, Copyright © 1990 by American Podiatric Medical Association

JOURNAL ARTICLE

Vitamin C influence on localized adjuvant arthritis

RH Davis, KY Rosenthal, LR Cesario and GR Rouw
Pennsylvania College of Podiatric Medicine, Philadelphia 19107.

This work attempts to determine the influence of vitamin C on locally induced inflammation and arthritis in rat paws, as measured by rat paw swelling, polymorphonuclear leukocyte infiltration, pain, and surface skin temperature. Daily subcutaneous administration of 150 mg/kg of vitamin C over 20 days reduced arthritic swelling, increased pain tolerance, and decreased polymorphonuclear leukocyte infiltration, with no significant change in surface temperature. Vitamin C may provide podiatrists with a supplemental or alternative treatment for patients with rheumatoid arthritis.


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H.-A. Lehr, B. Frei, A. M. Olofsson, T. E. Carew, and K.-E. Arfors
Protection From Oxidized LDL–Induced Leukocyte Adhesion to Microvascular and Macrovascular Endothelium In Vivo by Vitamin C but Not by Vitamin E
Circulation, March 1, 1995; 91(5): 1525 - 1532.
[Abstract] [Full Text]


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Copyright © 1990 by the American Podiatric Medical Association.