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Journal of the American Podiatric Medical Association, Vol 81, Issue 6 288-293, Copyright © 1991 by American Podiatric Medical Association

CLINICAL TRIAL

Treatment of painful diabetic neuropathy with capsaicin 0.075%

NM Scheffler, PL Sheitel and MN Lipton
American Center for Foot Health Research, Baltimore, MD 21227.

An 8-week, double-blind, vehicle-controlled study was conducted to determine the effectiveness of topical capsaicin 0.075% cream in relieving pain associated with diabetic neuropathy. Patients were selected who experienced moderate to very severe pain, which interfered with sleep or activities on a daily basis, and who were unresponsive or intolerant to conventional therapy. The results after 8 weeks showed a statistically significant difference in favor of the capsaicin-treated patients, with 90% of these patients improved. The results of this study indicate that topical capsaicin 0.075% cream is safe and effective in managing painful diabetic neuropathy.


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Copyright © 1991 by the American Podiatric Medical Association.