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Journal of the American Podiatric Medical Association, Vol 86, Issue 6 244-248, Copyright © 1996 by American Podiatric Medical Association

JOURNAL ARTICLE

Genetics of split hand and split foot. A case study

BD Caldwell
Department of Podiatric Medicine, Ohio College of Podiatric Medicine, Cleveland 44106, USA.

Split hand and split foot is an autosomal dominant disorder that displays several genetic phenomena. These include variable expressivity, reduced penetrance, and segregation distortion. Although not fully understood at the molecular level, all are important in determining transmission of the gene thought to be mapped to the long arm of chromosome 7 (7q21.3-q22.1). These phenomena, therefore, have significant implications for inheritance of split hand and split foot and for proper referral for genetic counseling.




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Copyright © 1996 by the American Podiatric Medical Association.