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Journal of the American Podiatric Medical Association, Vol 88, Issue 4 192-197, Copyright © 1998 by American Podiatric Medical Association

JOURNAL ARTICLE

Wolf-Hirschhorn syndrome. Review of the literature and three case studies

P Thomson
Fife Healthcare NHS Trust, Dunfermline, Scotland.

Wolf-Hirschhorn syndrome is a rare chromosomal abnormality caused by loss of material from the distal aspect of the short arm of chromosome 4. Characteristics include marked prenatal and postnatal growth retardation with psychomotor delay, profound mental deficiency, distinctive facies, and midline defects. Features that may affect the lower limb include lordosis, scoliosis, hypotonia, talipes equinovarus, and lesser-toe anomalies. This article reviews the literature on this rare syndrome and presents three case studies.




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Copyright © 1998 by the American Podiatric Medical Association.