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Journal of the American Podiatric Medical Association, Vol 88, Issue 7 332-336, Copyright © 1998 by American Podiatric Medical Association

CLINICAL TRIAL

Comparison of salicylic acid and urea versus ammonium lactate for the treatment of foot xerosis. A randomized, double-blind, clinical study

MB Jennings, D Alfieri, K Ward and C Lesczczynski
New York College of Podiatric Medicine, NY 10035, USA.

Xerosis is defined as dehydration of skin characterized by redness, dry scaling, and fine crackling that may resemble the crackling of porcelain. The present double-blind trial was a randomized paired comparison study evaluating the keratolytic effect of 5% salicylic acid and 10% urea ointment (Kerasal) on one foot and 12% ammonium lactate lotion (Lac-Hydrin) on the other foot in mild-to-moderate xerosis. Seventy patients were initially enrolled in the trial. Fifty-four patients were evaluated after 2 weeks of treatment; of those 54 patients, 39 were evaluated after 4 weeks of treatment. Although there was significant improvement in severity of xerosis after 2 and 4 weeks of treatment, there was no statistically significant difference between treatment groups. Irrespective of the mechanism of action, this study shows that both Kerasal and Lac-Hydrin 12% lotion result in reduction in the severity of xerosis after 4 weeks of therapy.


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M. B. Jennings, L. Logan, D. M. Alfieri, C. F. Ross, S. Goodwin, and C. Lesczczynski
A Comparative Study of Lactic Acid 10% and Ammonium Lactate 12% Lotion in the Treatment of Foot Xerosis
J Am Podiatr Med Assoc, March 1, 2002; 92(3): 143 - 148.
[Abstract] [Full Text] [PDF]


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Copyright © 1998 by the American Podiatric Medical Association.