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Journal of the American Podiatric Medical Association, Vol 89, Issue 10 502-505, Copyright © 1999 by American Podiatric Medical Association

CLINICAL TRIAL

Ammonium lactate 12% lotion versus a liposome-based moisturizing lotion for plantar xerosis. A double-blind comparison study

JJ Uy, AM Joyce, JP Nelson, B West and JR Montague
Barry University School of Graduate Medical Sciences/Cedars Medical Center, Miami, FL, USA.

Two emollients, ammonium lactate 12% lotion and a liposome-based moisturizing lotion, were compared in a double-blind test for efficacy in the treatment of plantar xerosis. A total of 43 out of 57 participants (75%) with bilateral plantar xerosis followed instructions completely and applied the lotions (one to each foot) twice daily for 4 weeks. Each participant was evaluated once a week for 6 weeks (the final 2 weeks for evaluation of post-treatment regression) to determine xerotic grade (degree of dryness) and treatment effectiveness. With both lotions, significant improvement began during the second week of treatment and continued into the fourth week. There were no significant differences between the two lotions in the 6-week patterns of either xerotic grade or treatment effectiveness.


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M. B. Jennings, L. Logan, D. M. Alfieri, C. F. Ross, S. Goodwin, and C. Lesczczynski
A Comparative Study of Lactic Acid 10% and Ammonium Lactate 12% Lotion in the Treatment of Foot Xerosis
J Am Podiatr Med Assoc, March 1, 2002; 92(3): 143 - 148.
[Abstract] [Full Text] [PDF]


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Copyright © 1999 by the American Podiatric Medical Association.