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Journal of the American Podiatric Medical Association Volume 92 Number 1 34-37 2002
Copyright © 2002 American Podiatric Medical Association

Cellular Senescence and Matrix Metalloproteinase Activity in Chronic Wounds

Relevance to Debridement and New Technologies

Gerit D. Mulder, DPM, MS* and Jerry S. Vande Berg, PhD{dagger}

* Director of Research and Education, Clinical Director, University of California San Diego Medical Center, Regional Burn Center/Wound Treatment and Research Center, 200 W Arbor Dr 8896, San Diego, CA 92103-8896.
{dagger} Director, Core Clinical and Research Imaging Facility, Research Service V-151, Veterans Administration Medical Center, San Diego, CA.

Abstract

A prolonged inflammatory response may adversely affect wound closure. Delayed wound closure and extended exposure to chronic wound fluid may also affect cellular activity in a wound bed and result in cellular senescence. Prolonged inflammation and cellular senescence may adversely affect the efficacy of topically-applied biological agents, including growth factors. Appropriate wound bed preparation and debridement are necessary to improve clinical outcomes of new technologies.(J Am Podiatr Med Assoc 92(1): 34-37, 2002)






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Copyright © 2002 by the American Podiatric Medical Association.