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A Comparative Study of Lactic Acid 10% and Ammonium Lactate 12% Lotion in the Treatment of Foot Xerosis

Maureen B. Jennings, DPM^*, Loretta Logan, DPM, MPH, Donna M. Alfieri, DPM, Charles F. Ross, DPM, Susan Goodwin, PhD^|| and Christine Lesczczynski^¶

^* Assistant Dean for Research; Professor of Medicine, New York College of Podiatric Medicine. Mailing address: 1800 Park Ave, New York, NY 10035.
Assistant Professor of Orthopedics, New York College of Podiatric Medicine.
Assistant Professor of Medicine, New York College of Podiatric Medicine.
Assistant Dean for Student Affairs and Admissions; Clinical Associate Professor of Medicine, New York College of Podiatric Medicine.
^|| Assistant Professor, Department of Health Quantitative Sciences, New York Medical College, Valhalla, NY.
^¶ Clinical Research Associate, New York College of Podiatric Medicine.

Abstract

Xerotic skin is a pattern of reaction to a variety of disorders that have abnormalities of desquamation in common. This double-blind, randomized clinical trial investigated the effect of Lactinol (Pedinol Pharmaceuticals, Farmingdale, New York) versus Lac-Hydrin 12% (Bristol-Myers Squibb, Princeton, New Jersey) lotion in mild to moderate foot xerosis. Clinical assessment of xerosis was performed at baseline visit, and the designated sites were evaluated at 2 and 4 weeks after treatment began. Of the 53 patients enrolled, 18 were excluded from analysis. Although both treatment groups had significantly improved xerosis scores after 2 and 4 weeks of treatment, no statistically significant difference was observed. Of the 44% of patients who did express a preference, 72% preferred Lactinol, which may account for the 20% increase in its overall use in the study. (J Am Podiatr Med Assoc 92(3): 143-148, 2002)