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Treatment of Scleroderma Skin Ulcers Using Becaplermin Gel and Hydrocolloid Membrane

Jerry Yoon, DPM^*, Joseph Giacopelli, DPM, David Granoff, DPM and Wesley Kobayashi, DPM

^* Submitted during second-year residency, Fountain Valley Regional Hospital, Huntington Beach, CA. Mailing address: 1450 SW Marlow Ave, Portland, OR 97225.
Diplomate, American Board of Podiatric Surgery; Fellow, American College of Foot and Ankle Surgeons; Director, Podiatric Surgical Residency Program, Fountain Valley Regional Hospital, Huntington Beach, CA; private practice, Huntington Beach, CA.
Diplomate, American Board of Podiatric Surgery; Fellow, American College of Foot and Ankle Surgeons; Co-director, Podiatric Surgical Residency Program, Fountain Valley Regional Hospital, Huntington Beach, CA; private practice, Fountain Valley, CA.
Diplomate, American Board of Podiatric Surgery; Fellow, American College of Foot and Ankle Surgeons; private practice, Huntington Beach, CA.

Abstract

Skin ulcers can be very painful and detrimental in patients with systemic sclerosis, or systemic scleroderma. A brief review of scleroderma skin ulcers is presented, as well as a case study that demonstrates the effectiveness of becaplermin gel supplemented by oral immunosuppressive agents in the treatment of ulcers resulting from systemic sclerosis. The time to healing (approximately 3 months) was comparable to that associated with the oral agents and surgical interventions specifically designed to help heal scleroderma ulcers. Except for incisional biopsy, no surgical procedures were performed. (J Am Podiatr Med Assoc 92(6): 350-354, 2002)

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