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Topical Treatments for Onychomycosis

A Historical Perspective

Myron A. Bodman, DPM^*, Lisa Feder, PhD and Angela M. Nace, PharmD

^* Cleveland Foot and Ankle Clinic, Ohio College of Podiatric Medicine, Cleveland.
Scientific Connexions, Newtown, PA.
This article was supported by an unrestricted educational grant from Dermik Laboratories, Berwyn, Pennsylvania. Drs. Feder and Nace both received funding from Dermik Laboratories. Dr. Bodman has received monetary compensation for speaking engagements from Dermik Laboratories.

Corresponding author: Myron A. Bodman, DPM, Cleveland Foot and Ankle Clinic, Ohio College of Podiatric Medicine, 10515 Carnegie Ave, Cleveland, OH 44106.

Abstract

Topical treatment of onychomycosis, in contrast to systemic oral therapy, allows the patient to apply medication directly to the affected area, thereby decreasing the potential for adverse events and drug interactions. Historically, several topical antifungal agents have been used in the treatment of onychomycosis; however, the evidence for their effectiveness is based on very limited data or anecdotal reports. Recently, the development of new, effective topical agents has renewed interest in this form of therapy. As clinical experience with newer topical agents expands, they may be found to be an effective option for the treatment of onychomycosis. (J Am Podiatr Med Assoc 93(2): 136-141, 2003)