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Journal of the American Podiatric Medical Association
Volume 93 Number 3 229-233 2003
Copyright © 2003 American Podiatric Medical Association

Charcot-Marie-Tooth Disease and Vincristine

Ángel M. Orejana-García, DP*, Javier Pascual-Huerta, DP{dagger} and Andrés Pérez-Melero, MD, PhD{ddagger}

* Department of Podiatric Pathology, E.U. Enfermería, Fisioterapia y Podología, Universidad Complutense de Madrid, Madrid, Spain.
{dagger} Clínica Universitaria de Podología, Universidad Complutense de Madrid, Madrid, Spain.
{ddagger} Department of Geriatrics, E.U. Enfermería, Fisioterapia y Podología, Universidad Complutense de Madrid, Madrid, Spain.

Corresponding author: Ángel M. Orejana-García, DP, Department of Podiatric Pathology, E.U. Enfermería, Fisioterapia y Podología, Universidad Complutense de Madrid, Av. Complutense s/n, 28040 Madrid, Spain.

Abstract

This article reports on a case of sensorimotor neuropathy in a 55-year-old man that developed after vincristine therapy. Subsequent biopsy of the sural nerve and electromyographic studies revealed the presence of Charcot-Marie-Tooth disease. Only 17 patients who developed severe neuropathy with very low accumulated doses of vincristine have been described in the literature. Pain and lateral ankle instability were treated with a functional orthosis. Orthopedic treatment and the biomechanical basis of foot and ankle problems in patients with vincristine therapy–induced Charcot-Marie-Tooth disease are discussed. (J Am Podiatr Med Assoc 93(3): 229-233, 2003)






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Copyright © 2003 by the American Podiatric Medical Association.