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Analgesic Efficacy of Valdecoxib for Acute Postoperative Pain After Bunionectomy

Richard Pollak, DPM, MS ^*, Gary A. Raymond, DPM , Richard M. Jay, DPM , Howard J. Hillstrom, PhD , Kieran T. Mahan, DPM, MS , Dennis Riff, MD , Ellis L. Jacobs, DPM ^||, Mark T. Brown, MD ^¶ and Kenneth M. Verburg, PhD ^¶

^* San Antonio Podiatry Associates, San Antonio, TX.
Advanced Regional Center for Clinical Research, Altoona, PA.
Temple University School of Podiatric Medicine, Philadelphia, PA. Dr. Hillstrom is now with the Hospital for Special Surgery, New York, NY.
AGMG Clinical Research, Santa Ana, CA.
^|| Horizon Institute for Clinical Research, Hollywood, FL.
^¶ Pfizer Global Research and Development, Ann Arbor, MI.

Corresponding author: Richard Pollak, DPM, MS, San Antonio Podiatry Associates, 8042 Wurzbach Dr, Ste 450, San Antonio, TX 78229.

Abstract

Two randomized, double-blind, placebo-controlled studies assessed the analgesic efficacy of valdecoxib in patients with moderate-to-severe pain after bunionectomy. Study 1 (N = 374) assessed the efficacy of two regimens of valdecoxib on the day after surgery (valdecoxib, 40 mg, with a 20-mg redose [n = 127]; valdecoxib, 40 mg, with a placebo redose [n = 122]; and placebo/placebo [n = 125]), and study 2 (N = 478) examined the efficacy of two different multiple-dose regimens on postoperative days 2 through 5 (valdecoxib, 20 mg, twice daily [n = 160]; valdecoxib, 20 mg, once daily [n = 159]; and placebo [n = 159]). Valdecoxib provided significant pain relief and reduced the use of opioid rescue medication. This efficacy was accompanied by improved global scores, decreased pain interference with function, and increased patient satisfaction. (J Am Podiatr Med Assoc 96(5): 393–407, 2006)

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