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Journal of the American Podiatric Medical Association
Volume 96 Number 6 482-488 2006
Copyright © 2006 American Podiatric Medical Association

Efficacy of Concentrated Autologous Platelet-Derived Growth Factors in Chronic Lower-Extremity Wounds

Jody Peter McAleer, DPM *, Eric Kaplan, DPM * and Gianni Persich, DPM *

* Division of Podiatric Surgery, Department of Orthopaedics, Mount Sinai Hospital of Queens, Mount Sinai School of Medicine, Astoria, NY.

Corresponding author: Jody Peter McAleer, DPM, 820 Lydig Ave, Bronx, NY 10462.

Abstract

The efficacy of concentrated autologous platelet-derived growth factors in the healing and closure of chronic lower-extremity wounds was evaluated in 24 patients with 33 lower-extremity wounds treated previously for at least 6 months using traditional methods. Surgical wound debridement was performed to convert chronic ulcers into acute wounds. Concentrated autologous platelet-derived growth factors and thrombin were applied to the wound bases and protected with a nonadhering compression dressing that remained intact for 7 days. Wounds were evaluated and the concentrate was reapplied every 2 weeks. Wound closure and complete epithelialization was achieved in 20 wounds. Seventy-five percent or greater wound closure was obtained in three wounds, 50% to 74% closure in three wounds, and 25% to 49% closure in two wounds. Five wounds displayed no improvement. Mean time to complete closure was 11.15 weeks. The application of concentrated autologous platelet-derived growth factors and thrombin resulted in substantial wound healing and wound-diameter reduction. This technique constitutes a safe and effective treatment option and avoids lengthy treatment periods that increase the potential for infection. (J Am Podiatr Med Assoc 96(6): 482–488, 2006)






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Copyright © 2006 by the American Podiatric Medical Association.